The present work analyses the state and development prospects of metrological support and standardization of in the field of measuring surface density, thickness and chemical composition of coatings. The main characteristics of the State Primary Measurement Standard GET 168-2015 and developed multiparameter reference materials are described.

The paper presents information on the development of a new certified reference material (CRM) for mass fraction of dioxins in animal fat, with established metrological traceability. A procedure for preparing and certifying CRM material is given. The GC–LRMS method with isotopic dilution was used as an analytical method for establishing certified characteristics. The uncertainties due to inhomogeneity and instability of the CRM material were estimated in order to account for their contribution to the uncertainty of certified values. In addition, the results of interlaboratory comparisons (ILC) for an experimental batch of the developed CRM are presented. Measurement results provided by ILC participants are shown to be in good agreement with the certified characteristics of the CRM. The certified values of dioxin mass fractions (PCDF group) in the CRM material are established to vary from 1 to 1000 ng / kg, with the relative expanded uncertainty ranging from 10 to 20 %.

Human immunoglobulin and human albumin products can negatively affect patients’ health. The residual content of haemagglutinins, anti-D antibodies, prekallikrein activator, as well as the level of anticomplementary activity, are controlled during both production and testing for compliance with normative documentation. Methods for their quantitative evaluation are based on the effects of erythrocytes hemolysis or agglutination and on the amidolytic product properties of cascade reactions. These methods require the obligatory use of reference materials (RMs). The development of RMs, acting as the carrier of the quantitative characteristics of the human immunoglobulins and human albumin impurities, is fraught with the difficulty of selecting a candidate, substantiating the certification methodology, and determining the relevant characteristics. In this research, we used human immunoglobulin solutions with normalized haemagglutinin content, anti-D antibodies or anti-complementary activity in a different range, whose quality was studied using haemagglutination and chromogenic methods, and the complement fixation test. Methodological approaches to the RM development and certification were justified using system analysis and forensic audit methods. The results demonstrate the necessity of using RMs to assess the stability of analytical work by applying anti-complementary activity determination, haemagglutinin content or anti-Dantibody methods. It is established that RMs allow the quantitative content of haemagglutinins, anti-D antibodies and prekallikrein activator to be established. The value of the CRM characteristics should be approximated to the qualitative composition of these impurities in the analysed products, but in amounts not detectable (to produce negative RM components) or exceeding permissible maxima (to produce positive RM components).

Introduction. The article presents an approach to the development of interlaboratory comparison test samples and respective reference materials for use in the metrological assurance of measurements of hazardous substances in the ambient air. Materials and methods. Solid and liquid sorbents, as well as air filters were used in the experiments. Measurement methods comprised photometry, atomic absorption spectrometry, inductively coupled plasma atomic emission spectrometry. Results. An optimized algorithm for developing multi-purpose test samples that can be used for the metrological assurance of a large number of methods for analysing ambient air is presented. Discussion and conclusions. The described approach has been used to develop test samples for laboratory proficiency testing and respective reference materials, which can be used in the certification of procedures for analysing ambient air quality, calibration of measurement instruments, as well as in the internal and external quality control of results obtained during ambient air quality measurements.

This article presents the description, metrological characteristics and application of State primary standards developed at the All-Russian Research Institute of Physicol-Technical and Radio-Technical Measurements (VNIIFTRI). These include the state primary standards for pH and pX in aqueous solutions, units of the dispersed parameters of aerosols, suspensions and powdery materials, units of the mass fraction and mass (molar) concentration of inorganic components in aqueous solutions based on gravimetric and spectral methods of analysis. In addition, the article discusses R&D projects that are currently being realized at VNIIFTRI, including the production of standard-titres and buffer solutions for pH-metry, as well as working standards for assessing the activity of Na⁺, K⁺, F^- , Cl^- , Br^- , I^- , NO_3- (pX) ions in aqueous media.